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DeCS
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Descriptor English:
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Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
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Descriptor Spanish:
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Fosfatidilinositol-3,4,5-Trifosfato 5-Fosfatasas
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Descriptor Portuguese:
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Fosfatidilinositol-3,4,5-Trifosfato 5-Fosfatases
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Synonyms English:
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SHIP Phosphatases
Src Homology 2 Domain-Containing Inositol Phosphatases
Phosphatases, SHIP
Src Homology 2 Domain Containing Inositol Phosphatases
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Tree Number:
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D08.811.277.352.650.624.750
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Definition English:
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Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates. |
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History Note English:
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2017
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Allowable Qualifiers English:
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Record Number:
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56477
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Unique Identifier:
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D000072183
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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